Vortex generators are the devices for remixing and increasing speed of boundary layer. As such they need to be applied in the place where they improve aero efficiency of existing design, not to alter it as they are really not capable of doing it.
The was a study which used a combination of VG and spoiler an succeeded in completely eliminating trail wake. But as I recall they tried 26 different combinations in wind tunnel, something we can't.
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