[skyking]

All those things you are talking about are variable to some extent. AOA applies to any wing, no matter how light.
all things equal, it takes a higher AOA and thus induced drag to fly a heaver plane vs a lighter one. Speeding it up won't change that fact, the heavier plane will have a higher AOA than the lighter one, more drag.
Now there are tradeoffs in operation. Sometimes it pays to go higher with tailwinds for example.
The airlines will often fly a heavily loaded plane at a lower altitude until some fuel burns off, then go on up to a better cruising altitude. This is because the AOA is going to be out of the efficient range a the higher altitude and weight.