If it's a slow-blow fuse, it should be fine at 250 amps. Those ANL and such tend to be slow-blow, assuming that's what the OP went for.
2 gauge wire should be fine, assuming your battery isn't border-line for being able to just kick over the starter. Welding-wire used for welding at 2 gauge is rated for 400 amps at up to 50' of it. Not sure if it's been mentioned, but you should probably run a negative wire to the engine block as well, not just straight to the chassis, to keep voltage drop to a minimum. If you're running it to both, it could potentially be lighter gauge.
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