I would do a grille block. In winter it's fine. Watch your temps. Use synthetics for engine oil and transmission since those keep temps down. Using some good quality extra heavy duty coolant will help in that department too.
Cold Front Grille Insert 1998 to 2003 Chevy S10 Pickup or Chevy Blazer#88475 | eBay
If you wanna do more on aero, do a coroplast belly pan from old election sign if you have friends in politics. Then get some smaller mirrors.
For 94-01 S10 F1 Manual Adjustable Chrome Finish Side View Mirror | eBay
Get a wiper cowl too...
Lund 25505 Polycarbonate Smoke Shadow Wiper Cowl for Sonoma/Jimmy/Bravada/S10 | eBay
Then you can get into friction modifiers for the engine, differential, wheel bearings using NMF and/or tungsten disulfide from lowerfriction.com
Have fun.