I've used winter tires on my Honda Odyssey since I bought it. They are awful in the snow without them. I notice about a 1-2 mpg drop vs the summer tires. The biggest difference is in the noise.
On my SUVs I've used M&S rated tires year round. I run Goodyear Wrangler GS-As (no longer made) on the Explorer and my daughter's Jeep Liberty. Good quiet year round tires. My Isuzu Trooper always worked best on Yokohama Geolanders, but the Explorer hated them.
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