You don't need hybrid to get a 40mpg pick up, just intelligent design. American type pickups are mostly toys. If you want to get real practicality with an open vehicle (if you have a shell on your pickup you're screaming 'I'm doing it wrong') then you get something like this:
https://trucksmithtarget.co.uk/
Easy loading from all sides and a secure space for an 8' ladder and tools, and a low load floor (how you're supposed to get a compressor or welder or table saw into a 4x4 pick up I don't know).
30mpg city worst case. 40+mpg city best case. Same over all size as an F150.
America simply isn't ready.