I don't think it's possible, but I'm really interested to see what you can do.
The only reason I don't think it's possible is that the Prius gets 50 MPG at 65 MPH, and it's gutless and very aerodynamic.
Here's a chart someone posted with a 7L Corvette, which is still very impressive.
I'd go for a 50 MPG at a lower speed as a goal. Maybe you can do it at 45 MPH.
BTW, I think there are methods to calculate how much power you need to produce at a given speed by doing coastdown tests on your car. You time how long it takes to coast from a starting speed to some lower speed, and by knowing the weight of the vehicle, you can determine with some degree of precision the aerodynamic drag.