I make no effort to measure the loss of fuel economy when running my Mazda3's air conditioner. When the weather is 90 degrees plus and the humidity close behind, who cares? Not me.
Because I live in a hot and humid state, my air conditioner is on almost all the time. If I removed the air conditioner, I doubt my fuel cost per mile would rise much above the 4.6 cents my car has achieved since it was bought new in 2015.
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