The smaller the car, the more things like LRR make a difference. People say non-LRRs on the Insight can cost 10 mpg or so if replaced with a tire with high rolling resistance.
Weight is also a consideration, larger tires are heavier. Unless the larger tire is LRR I'd go with the smaller LRR size.
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2013 Toyota Prius C 2 (my car)
2015 Mazda 3 iTouring Hatchback w/ Tech Package (wife's car)
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