Weight makes no difference to fuel economy if you're a hypermiler. Doubly so if you have a hybrid where a portion of your kinetic energy goes back into the battery. I've driven 60K in my vans and there's really no correlation between payload and fuel economy. More weight just means I glide longer. In a hybrid, more weight means more energy goes back into the battery.
At best, the payback will be measured in decades.
Smaller wheels will likely help, but it will be due to aerodynamics and lower rolling res.
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