With a big engine, I'd think gearing would have the biggest gains.
Then aero.
Then engine efficiency.
Then rolling resistance. (which is one of the easier things to deal with)
Then weight.
Finally accessories at the bottom of the list. Sure, they waste energy, but it's minor when compared to what it takes to keep a big engine spinning.
However you go about it, it will be interesting to see what gains you make where.
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