The difference in fuel consumption would get eaten up by the increased amounts of trips to gas stations.
In my car I fill up all the way each time, ends up beeing maximum 41L or so aka about 30 kg of fuel or about 66 lbs for the metricly impaired.
That's at most 3% of my cars weight between full and empty.
If I filled up halfway instead of full, I'd end up making my car 1,5% lighter, wich is insignificant.
Ditching the spare tire and losing some weight would likely make more of a difference than 15 kg less fuel...
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