Yeah, on an empty highway, speed is a huge factor in MPG. In my c-class, I used to just set the cruise to 80 and chill out to get about 27mpg. After raising the tires 10psi and slowing down to 65-68, I moved up to 32mpg.
For my long trips, leaving 10 minutes early won't do much. I do 1200mile round trip weekend business trips 1-2 times per month, so 60mph gives me 20 hours of driving vs 16 hours at 75mph. 4 hours is a big chunk of time...I think I'll compromise with 68-70 mph on these trips. Luckily, long trips with no city driving allow me to find a pretty direct correlation between speed and FE.
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