I tested it years ago. Double blind test on my wife's car. Added a 16 ounce bottle to the cavernous gas tank of a 4.6L town car. It appeared to at least improve fuel economy, but not enough to cover the cost of the 2 cycle oil. I would have her run it till the fuel light turns on, dump in the 2 stroke oil and fill it up. Same for the no 2 stroke oil tanks.
I would say yes it can improve fuel economy. And it may be economical for some vehicle and engine combinations.
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1984 chevy suburban, custom made 6.5L diesel turbocharged with a Garrett T76 and Holset HE351VE, 22:1 compression 13psi of intercooled boost.
1989 firebird mostly stock. Aside from the 6-speed manual trans, corvette gen 5 front brakes, 1LE drive shaft, 4th Gen disc brake fbody rear end.
2011 leaf SL, white, portable 240v CHAdeMO, trailer hitch, new batt as of 2014.
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