Yeah, but increased O2 concentration at lower pressure presents less fire hazard. Not sure exactly how that works out. Maybe at 40k ft, you'd need 100% O2. Not even sure if that is a viable solution.
Too complex though because adjusting the O2 concentration down as the plane descends is probably a bigger issue than simply pressurizing the cabin.
Still, air freight is going to become more and more important in an increasingly industrialized and global economy. Seems the low hanging fruit of improving efficiency would be a flying wing with a non-pressurized cargo hold.
...seems like most engineering problems would be solvable if carbon nanotubes were easy to implement.
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