Yep!
Since the RV is typically wider than the TV, the 'hard' leading edges on both sides are just shredding the flow. The flow will reattach downstream, but you're constantly paying for this region of turbulence which travels along with you.
An inflatable envelope, deployed while accelerating up the cruise speed could essentially seal the entire gap between TV and RV. You're no longer appreciably 'turning' while on the open road, so closing off the whole gap isn't an issue.
A look at what these gaps will do to wing sections will bring tears to your eyes ( Figure 134, page 228, THEORY OF WING SECTIONS, Abbott & Von Doenhoff ).
The inflation fan electrical current can be automatically disenabled below 45-mph, in anticipation of 'urban warfare'.