If you unplug the electrical connector from one injector, and somehow fool the engine management system into thinking it's still plugged in, you would save some gas. But the engine would run quite roughly and unevenly--possibly enough to damage it over the long haul. One advantage of the engines that are designed for cylinder deactivation is that they can set up the remaining cylinders to fire at even intervals, but killing one cylinder of a four-banger and leaving the other three as they were is going to have the engine shaking like crazy.
If you cannot fool the EMS into thinking the injector is still there, the engine will likely go into "limp-home mode", which traditionally means a nice safe rich mixture. Which won't be so good for your fuel economy, or for your engine either over the long haul.
-soD
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