Seems to me things shouldn't be built so sloppily we can assume way more than sufficient air exchange. A good system would measure the things that build up or become deficient in the air and set thresholds triggering air exchange.
I'm not sure what the biggest health concerns are with lack of exchange. Moisture buildup? Radon accumulation? I doubt it's CO2 buildup due to the sheer volume of air in houses.
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