E85 runs at an octane of 100-105 generally. Your car needs to be modified for a higher compression ratio to suck every bit of energy out of the E85. If you leave it at a normal compression ratio you will be losing some efficiency. Flex fuel vehicles are designed at the lower compression ratios for gasoline so they do not run E85 under ideal situations.
Someone else can probably give more practical details on modifications required, but one of the problems is E85 is acidic and electrically conductive. This means you need to remove any bare aluminum, magnesium, and rubber. This means you need to put in stainless steels tanks and fuel lines, sometimes lined with plastic. Also some motor oils are slightly base to eliminate the acidity of E85 and reduce wear and corrosion.
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