I've noticed a 12-15% drop with E10, so have my parents who drive the same route every day and for a while made a note as to what kind of gas they put in, the pure gas tends to cost 3-5% more and you get better mileage... and use less gas then if they left left the alcohol out all together!
read up on alcohol engines some time, alcohol engines and gas engines are about as close as gas and diesel engines, sure I've mixed bio-diesel in with my gas and that worked but I'm not sure if it was really worth it, if I used less gas, but I was running a bio-fuel.
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