If you can find some leaks in the attic, you can measure the distance from a chimney, vent pipe, etc, to the leak and then climb up top and seal everything you see in that general area. That may not fix it forever, but is a temporary solution. If you are talking about sealing the ridgeline vent in the attic, I would leave it. ventilation is good in an attic to prevent mold. I would seal all electrical penetrations, plumbing stacks, etc with spray foam, being careful not to put any flammable/non code compliant materials near any sources of heat (chimneys, recessed (can) lights). Also building an insulated and weatherstripped attic hatch can make a house a lot less leaky.
-James
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