One of the things I admire about the author of fuelsaving.info is that he sticks to his guns on the issue of valid empirical observations, even when it may weaken his own argument. He states up front that he hasn't tested acetone, and in the absense of any hard laboratory data either way, at the end he concedes:
"Admittedly, none of the above analysis proves that acetone doesn't help fuel economy."
(Though it's clear he's not actually giving any ground on his estimation of its worth.)
He also did allow that the addition of acetone may clean dirty fuel system components, so it may improve fuel economy simply by bringing things back into spec.
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