This has been tried many times without success. I tried a cylinder deactivation project back in 2007 by cutting the injectors, but it didn't work. The ECU expects more oxygen from the 02 sensors and dumps more fuel in the mix. Plus, the setup created quite a lot of vibration in . The only way this works is to physically close the valves and re-program the fuel delivery.
It's a great idea, but difficult to implement.
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“If we knew what we were doing, it wouldn't be called research” ― Albert Einstein
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