Maybe. Search this site for Sentra SE-R's test on wheel sizes and weights. He was quite thorough. [EDIT: what the heck, I did the search for you... you really should study these results:
http://ecomodder.com/forum/showthrea...tml#post246084. The bottom line is lighter beats heavier, sometimes even if heavier is also taller, but lighter and taller is best. Still, a lot will depend on the weight of the tires you put on and how much rolling resistance they add or subtract. That's why I answered "maybe."]