It looks to me like the central roué is better, also take ambient temps into account. The farther south the hotter it gets, more tempting to us ac and more grill opening needed.
From my experence without a side mirror, do it a week or two before the trip, you will be use to driveing without it by that point. On my car the side mirror removal was good for 1.6 mpg. Smoothe wheel covers were good for 1+ mpg. So I would put thoses up on the list of mods to do before the trip.
__________________
|