Make sure you choose the right size unit for the size of the room. The new compressors are super efficient and cheap to run. Do compare the yellow sticker efficiency ratings on various units. Spending a few more $$ for a higher quality unit can save more electricity.
In the long run you should check pricing on replacing your old central A/C unit with a newer, more efficient one. The efficiency is remarkable improved over even units sold 5 years ago. I don't see your location, but if humidity isn't a big problem where you live you could be very comfortable running the central unit (a new one) at 78-80 degrees for the first floor while adding spot cooling with ceiling or box fans.
__________________
|