In college, I had a 1995 GMC Sonoma (S10 clone), with a regular cab and short bed (4cyl, 5 speed, 2wd-- totally stripped-down model). I had a tonneau cover the whole time I owned it, and I definitely got several mpg less at highway speeds when I didn't have it on (not that often, but I definitely could tell). With the cover on, and normal driving, I got around 30mpg at 75mph. My all time high was 32mpg, without really trying, and before I ever heard of hypermiling.
But yeah, to keep on topic, keeping the tailgate up is better than down, and a tonneau cover is better still. It's not as good as fashioning a cap into a pseudo-kammback, but every little bit helps.
__________________
|