How about having a large, clear window section to see through with one of those rigid roll up covers from the bottom of that back to the tailgate?
That way large cargo could be hauled without needing to remove anything, until the cargo is large enough to require removal of the roll up cover and window section.
Could make the window hinge down and have some way to secure the rolled up cover inside. If you're hauling something that large you won't be using the inside rear view mirror anyway.
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