Especially in areas where they allow studded tires, there is much less road noise (and I believe better FE) by driving out of the "normal" position in the lane. For me in OR, that meant two wheels on or around the edge stripe of the road, and two near the center of the lane. Studs seem to chew up concrete or asphalt really badly...
I've noticed similar phenomena on a few roads here in the SF Bay Area of CA, where studded tires are not used. But it's much less common--and the edge of the road often has other debris on it (even just gravel) that can lead to extra noise and extra resistance.
-soD
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