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When riding efficiently, I got the same mileage on my 2001 ZX6R Ninja (carbed inline 4, ~100hp) as my current Ninja 650R (EFI inline twin, ~65hp). Both get about 50-55mpg.
When not riding efficiently, the ZX6R would get ~35mpg vs 45mpg for the 650R.
I also had a Suzuki Katana 600 (also a carbed inline 4) that got about the same mileage as the 650R.
I think there are too many other variables with motorcycles to worry too much about the number of cylinders for fuel economy reasons.
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