Look up "BSFC charts". Most automotive engines are most efficient at lowish RPMs and high (but not 100%) loads. As others have said, the computer will often enrich the fuel mixture as you near 100% load, which is bad. In my 5MT, I get the best economy when I shoot for about 80% load (as reported by the computer) at less than 2500RPM. The pedal position required to accelerate at that load changes based on RPM, however, so you can't just rely on pushing it a set amount. You really need instrumentation to get close to "perfection ", but I figure a good rule in an automatic is to accelerate at near the max rate you can without causing a downshift, and let it upshift as soon as possible.
That said, so long as you aren't revving it up, the biggest gains are too be found in the art of slowing down.
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