Wow.
Okay, the health issues suck - you don't need me to tell you that - and I wish the best of luck to you.
As to swapping in the 700r4, I say go for it. For your intended mission profile for the truck, there really aren't any big advantages to a manual over an automatic. You just get on the highway, get up to speed and cruise. I think the 4L60 will work too, just make sure it doesn't have any vacuum-predicated controls. Be sure you have the beefiest lockup torque converter for long-legged cruising and you're good to go.
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Lead or follow. Either is fine.
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