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Often the existing knuckles will not accept hubs that accept driveshafts. I'll give an example:
In Honda circles, AWD conversions are highly desirable. Typically one uses an Element or CR-V transmission and rear differential. Turns out Honda Insight front hubs have the same axle size as CR-V or Element rear differentials, so you see tube frame fabrication for mounting points to put Insight knuckles and, sometimes, even control arms, into the back of Civics. The steering arm becomes a "toe arm".
Fronts are probably easier than rears, given that the MR2's front suspension almost certainly shares parts with some FWD vehicle you can steal knuckles out of.
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