Best way to save weight with brakes is to get two piece rotors with aluminum hats, and to see if there are any calipers made of aluminum (if they aren't already) available for your vehicle.
Every fuel tank I've ever had has been plastic.
Wheels and especially tires are lower hanging fruit, however, since they're considerably farther away from the center of rotation.
Fuel economy gains from weight loss is virtually zero, but it does improve how the vehicle handles, accelerates, and stops.
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