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If you're shutting off all cylinders simultaneously I don't see a problem either (forced engine-off coasting, EOC).
If you're only shutting off a pair of cylinders while under load I see that as very bad. New engine designs that do this also hang a valve open on the cylinders when those injectors are shut off to prevent pumping losses when not generating power.
Hondas are sensitive to valve clearance settings and typically run a lot tighter than "normal" engines. Depending on engine design some of them can tighten up with wear which will toast the valves by failing to seat them in the head with enough force to seal against combustion pressure.
Running timing too advanced for your engine is bad because it could cause undetectable preignition, especially if you're running it as a 2cyl you might not hear the spark knocking over the externally-induced vibration.
Run fuel injector cutoff on ALL cylinders, or none at all. And properly maintain your engine for best economy.
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