i dont think i would take out the spare, i mean yes that would save weight, but then you have safety to consider.
i've found great gains with keeping top speed to 65 or under (60mph seems ideal for my car.) also, like 99metro said, coast alot and fill those tires! another thing is keep your windows closed, use fans first, and if too hot use a/c. not using a/c saved me greatly as well.
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