They won't increase longevity any, but buying a flow matched set of injectors in addition having a knife edge tune put on the engine's computer, will improve your mpg enough to measure.
The factory tune has slop built in to account for flow differences between injectors. Weirdly enough, it seems to be more cost-effective for the factory to spend millions developing things like cam phasing than to flow test every injector going into every car.
What the computer does, at least on GM cars, is during closed loop operation the computer adds or subtracts pulse width based on the feedback from the O2 sensors; when you floor it, however, the O2 sensors don't react fast enough to keep up with changing load conditions. So, the computer dumps what it thinks should be the right amount of fuel plus a little bit extra into the cylinders. If one of your injectors is somewhat lean compared to the others, this means the computer will add a bunch of fuel to ALL the cylinders to compensate, because it won't know WHICH injector is causing the problem.
So by getting a set of flow matched injectors, you eliminate the variance and thus the computer can run closer to its base calibration, always a good thing; and if you know a good tuner, he can change the car's programming to account for the more precise injectors.
I think DonR's concern about the uneven airflow is valid, but probably more important when racing. GM's V8 engines, in particular, because of their intake manifold shape, flow more air to the back cylinders than the front ones. Big power combinations like superchargers may even have to use bigger injectors on some of the cylinders to handle the increased air flow.
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