If replacing the camper shell with one flush with (same height as) the top of the cab is "in the cards", that would both streamline it AND reduce the frontal area. If not, I'd probably try to streamline the front above the cab. If it was me, I'd get some 2" styrofoam & carve it with saws, files & sandpaper until I had a nice "ramp" transitioning from the top of the windshield to the top of the camper, gradually curving so it's parallel with the camper top by the time it gets to it. And I'd try to have it continue down the sides, rounding off that front corner, coming up as far forward as you can without interfering with opening your door. You see that idea with commercial trucks & motorhome conversions sometimes. Then I'd slap it on with duct tape & do some "A-B-A testing" with the ScanGauge.
But I agree with Frank Lee - you'll probably see less than 1 MPG out of it. However - as MetroMPG says, "There's no "magic bullet", just magic buckshot". Do lots of little things, and you'll get the effect of doing a big thing. As long as there was ANY gains at all from your A-B-A testing, I'd say, make it permanent.
Does your truck have cruise control? That is EXTREMELY helpful for A-B-A testing. The ScanGauge, if utilized sufficiently, will be your AWESOME powerful tool in figuring out what works and what doesn't. I didn't start using the "trip" feature until recently, nor the throttle position display and/or engine load display either, but those can really be informative.
One, maybe "too obvious" thing you'll see here a lot is speed. If you're racing around going over the speed limit all the time, you're burning a lot of extra gas. One of the more enlightening things I did with my ScanGauge was went out & tested my MPG at different speeds - all the way from 80 mph down to 35 mph in 5 mph increments. Clearly, you can't get away with going 35 mph on a freeway, but if you're on a street or back road that lets you, and you happen to know (from your ScanGauge testing) that 40 mph is your best MPG speed, why not go 40 for a mile or two if it "works"?
Another biggie is the brakes. I just HATE hitting the brake pedal, because in my mind, I can see the gas just evaporating every time I do it. Someone else on here has a quote that goes something like, "Braking = turning gas into heat and brake dust". If you have hills on your route, instead of maintaining speed (by feeding it more gas) going up the hill, try holding the accelerator steady and letting the speed bleed off, then regain it going down the other side. That trick can help.
There is a mountain of stuff on this site, and it's not always too easy to find what you're looking for immediately. So if you don't see what you're looking for, ask, and one of the guys here will probably have your answer for you.
Oh, and WELCOME to the site!!!!!
Bill