High inflation pressure will reduce tire wear because of lessened heat and load on the tire.
Actually, The I4 will probably get you more than that. Those are based off of normal drivers. If I had a slightly smaller engine, I know I could be getting mid-upper 20's. You should be able to do much better than that with the V6 anyway. It's a 3.0, and it's more modern than mine, and I'm pulling 23's right now.
Drive 55, or if that's too "slow" for you drive 60, and no faster. after 60, your mileage drops like a rock. around 45-50 is best, but if you live near heavily populated areas, 55 is more like it, and don't pull the people will run you over if you drive too slow crap. If your driving in the right lane, people will just pull over into the left lane and pass. They don't just randomly run into slow drivers. Otherwise, there'd be a lot of wrecked cars from people hitting Semi's. Trust me, I've driven in and around the St. Louis area more than once, and there's 4 lanes to choose from. left people drive about 85+, and the right ones drive about 55-60. middle right is about 65-75, and middle left is about 75-85.
Drive only when you know the car will warm up all the way. you use a lot less fuel running the car warm (the o2 sensor doesn't run in open-loop, which is like having a faulty o2 sensor).
Keep a constant throttle on flat roads, Drive with load on hills and accelerate smoothly, and decelerate smoothly.
Those are just the simple tips. Hope you get better mpg's!