I've had a number of gasbikes as well as the 48v 1000w hub drive ebike I currently use as a daily driver/commuter & generally speaking to achieve the "at least 35mph" (sustained) on a motorized bicycle requires about 2-2.5hp. Electrics do have a torque advantage but as even 1000w is only 1.34hp and wind resistance is exponential, even the 1000w hub manages only 26mph sustained, so your 500w @ 22mph is actually doing really well.
Reducing the wind resistance will ofc help, but such provides only fractional improvements, a mph or so here & there - a good example is the difference between riding upright and in an areotuck, which while a major difference in frontal area the gain at max on my ebike is about 1.5mph, about the same as the difference between smooth street slicks and knobby tires.
So while everything does add up, aeromods w/the ebike application & at these speeds provide more of a gain in a range return than a significant maximum speed - achieving the sustained speed you desire is going to require a fairly substantial increase in power, necessitating a motor upgrade & taking a very serious toll on your range...
Is it worth it? That's up to the rider ofc lol - it all depends on what your priorities are (& budget), but given your stated concerns I would suggest that 25-30mph is a more realistic expectation even with the "48V/1200W motor" upgrade you're considering (which is 1.6hp) but the hills would no longer be an issue.
I agree that the common rack mounted battery packs make for an unbalanced bike due to the high center of gravity - have you considered mounting your batteries in panniers? Wheel load is a concern, but you shouldn't be breaking spokes w/only an extra 16-30lbs... that sounds like another issue such as rim flex (single wall) and/or maladjusted spoke tension. I upgrade to lightweight but very strong & stiff double walled alloy rims for this "high speed" use with the added weight, they can be had quite inexpensively if the "big" brand names are ignored - try 'Alex Rims' for a reputable, but inexpensive alternative.
As you're in Kentucky this one may not be as simple as it could be, but for areomods & concealing/protecting your batteries - the heavy gauge shrink wrap used for off season boat storage has lots of potential. It's extremely easy to use, durable and very inexpensive as you'll only need the cut-offs, some scraps left over from a single boat wrap... which us the difficult part as you've probably not a lot of marinas where you're at lol
Still, it's a thought
edit: forgot, the 'Acclaim Double Black Kickstand' (amazon) is a very simple & sturdy aluminum center stand - I'd very strongly recommend replacing the treacherous side/kickstand on any motorized bicycle due to the weight