The gain will depend on what type of driving you do most. If it's mostly hi-way driving, I say do it. If you do more city driving, then the gains might be great.
On my daily driver, an S-10 pick-up, w/ 3.08 axle, 4spd o/d trans, was getting approximately 25 mpg. At 70mph=2,000 rpms.
I added an add on overdrive to it. Mpg went close to 30mpg(not at 70mph). At 70 mph=1550rpms or so. Its been awhile since I've been to 70mph, I mostly drive 55mph at 1150-1200rpms. My total overdrive ratio is around 0.55, so my 3.08 ratio is nearly half in top gear.
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