I did the same math that those wont gain their price difference in their lifetime or at least it would took near 170 000 kilometers in my car. The difference is 2% (figure taken from tire tests) in consumption to the second best (if efficientgrip is not taken into account). However if your goal is purely to achieve low consumption and best LRR those are your tire choice options!
Isnt tirerack purely based on consumer reports of the tires so no actual tests?
When I changed my Toyos under my car my costdown test end speeds went to highest levels so far!. My test is in a 1.5 km long downhill where the start speed is 100km/h (60mph) end speeds rose from 74 to 76 km/h. Also in the highway I now get very good consumption figures due to taller tires
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What you mentioned about the safety issue I think it is flushed to the toilet when/if? you pump your tires to 45 PSI. Tires loose lots of grip when driven at high tire pressures. But when driving normally there will be enough grip for most situations. People have driven a lot worse tires with 20 years ago and no accidents. The safety is in your head mostly, if you drive like nut you need lots of grip but if you hypemile lot of less is enough.
By the way those toyo 350 maybe even werent the toyos best LRR tires because they do eco tires for some toyotas etc ecomodels. You should find good size for you. The tire choosing is very difficult, it took one month for me
You can also level your car with smaller tires in the rear as I have done
. Now my rear tires are same toyos in 165/70/R13 with aluminium wheels they are 5,2kg lighter than the front tires with steel rims!