The only drawback to the USB is then you'll have 2 USB ports, and if you accidentally plug into the wrong one you might fry something. Other than that, I like it.
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Winter daily driver, parked most days right now
He's got a USB "B" Female jack for connection to the PC (Via standard USB A-B Male-Male cable like printers use) and a USB "A" Female jack to go the the car for I/O and 12V.
USB A-A Male-Male cables exists, but they're pretty rare - that alone will help alleviate any "mis-plugging."