Unfortunately I doubt the Defender will be anywhere near as fuel efficient BUT they may last a really long time which would them very close in total cost per mile. There are two test reports coming out soon from TireRack.com and Consumer Reports so keep an eye out.
Until then, here is my new best tank on these tires. There was quite a bit of pulse & glide used on this tank. I can't post a pic from my iPad so:
Results: 71.7mpg over 702.5 miles
Here are the results on my downhill 48mile commute plus a bunch of pulse & glide for the remaining miles.
Results: 95.9mpg over 233 miles.