I touched on this idea a while back in my Paseo build thread. I took some foam pipe insulation and filled the gaps around the frame and radiator as shown below.
Before
After
Before
After
However, I honestly don't think this helps very much since there are much larger holes elsewhere where air can bypass the radiator. For example, there is a gap around each headlight hole. So, the idea behind this thread is, how can we effectively block off the other areas, or duct air to the radiator to eliminate air leakage around it?