Define "worthwhile."
Most individual changes will be undetectable in the normal variability of tank-by-tank results. (Not the same as saying they don't work, just that the impact is small.)
I definitely wouldn't do a rear window spoiler on a sedan. That separates flow near the maximum cross section size. I'd consider a small decklid spoiler though. (Like the Civic Hybrid used.)
Off the top of my head, I'd consider (in order of effectiveness & ease):
- partial grille block (with ScanGauge to monitor coolant temps)
- passenger mirror delete
- smooth wheel discs
- passenger wiper delete / cowl block
- lower air dam
- rear wheel skirts